Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
adrb2_human 32 1.31x31 TM1 W => Ter stop gained 8.237e-06 1 121402 0 None None
adrb2_human 152 4.44x44 TM4 V => SerfsTer3 frameshift 8.236e-06 1 121412 0 None None
adrb2_human 172 4.64x64 TM4 H => ThrfsTer42 frameshift 8.236e-06 1 121412 0 None None
adrb2_human 263 6.25x25 TM6 K => SerfsTer4 frameshift 8.238e-06 1 121388 0 None None GP (contact)
adrb2_human 3 N-term Q => K missense 4.961e-05 6 120936 0 nan 0.024
adrb2_human 4 N-term P => H missense 2.479e-05 3 121022 0 nan 0.001
adrb2_human 5 N-term G => R missense 8.26e-06 1 121066 0 nan 0.415
adrb2_human 7 N-term G => S missense 1.651e-05 2 121164 0 0.78 0.078
adrb2_human 7 N-term G => C missense 1.651e-05 2 121164 0 0.04 0.731
adrb2_human 7 N-term G => V missense 8.253e-06 1 121164 0 0.18 0.261
adrb2_human 8 N-term S => R missense 8.25e-06 1 121206 0 0.02 0.397
adrb2_human 9 N-term A => T missense 1.65e-05 2 121232 0 0.39 0.01
adrb2_human 15 N-term N => D missense 8.242e-06 1 121330 0 0.08 0.214
adrb2_human 15 N-term N => S missense 0.000239 29 121336 0 0.29 0.018
adrb2_human 16 N-term G => R missense 0.4204 51009 121346 11077 0.17 0.143
adrb2_human 19 N-term A => V missense 8.238e-06 1 121384 0 0.3 0.0
adrb2_human 19 N-term A => E missense 8.238e-06 1 121384 0 0.46 0.001
adrb2_human 25 N-term T => M missense 8.238e-06 1 121394 0 0.01 0.24
adrb2_human 27 1.26x26 TM1 E => Q missense 0.6834 82949 121380 29384 0.47 0.008
adrb2_human 30 1.29x29 TM1 E => G missense 8.237e-06 1 121402 0 0.04 0.025
adrb2_human 35 1.34x34 TM1 G => S missense 8.237e-06 1 121408 0 0.09 0.554
adrb2_human 39 1.38x38 TM1 V => I missense 2.471e-05 3 121406 0 0.2 0.0
adrb2_human 40 1.39x39 TM1 M => V missense 8.237e-06 1 121408 0 0.02 0.448
adrb2_human 41 1.40x40 TM1 S => P missense 8.237e-06 1 121408 0 0.02 0.6
adrb2_human 43 1.42x42 TM1 I => M missense 2.471e-05 3 121404 0 0.09 0.957
adrb2_human 44 1.43x43 TM1 V => I missense 5.766e-05 7 121404 0 0.14 0.145
adrb2_human 54 1.53x53 TM1 V => I missense 1.648e-05 2 121392 0 0.01 0.999 LB (hydrophobic)
adrb2_human 60 1.59x59 TM1 K => N missense 8.241e-06 1 121350 0 0.0 0.441
adrb2_human 62 12.48x48 ICL1 E => D missense 8.242e-06 1 121326 0 0.09 0.032
adrb2_human 66 2.37x37 TM2 T => M missense 8.247e-06 1 121250 0 0.0 0.994
adrb2_human 69 2.40x40 TM2 N => S missense 0.0009157 111 121220 1 0.0 0.884 LB (polar (hydrogen bond), Van der Waals)
adrb2_human 73 2.44x44 TM2 T => S missense 1.65e-05 2 121184 0 0.08 0.015
adrb2_human 74 2.45x45 TM2 S => L missense 8.252e-06 1 121180 0 0.0 1.0
adrb2_human 82 2.53x53 TM2 M => K missense 8.257e-06 1 121106 0 0.0 0.998
adrb2_human 83 2.54x54 TM2 G => C missense 8.258e-06 1 121092 0 0.0 0.999
adrb2_human 83 2.54x54 TM2 G => D missense 8.258e-06 1 121092 0 0.0 0.998
adrb2_human 88 2.59x58 TM2 P => H missense 8.257e-06 1 121104 0 0.0 0.998
adrb2_human 91 2.62x61 TM2 A => T missense 8.258e-06 1 121098 0 0.01 0.995
adrb2_human 95 2.66x65 TM2 L => V missense 3.3e-05 4 121214 0 1.0 0.009
adrb2_human 97 2.68x67 TM2 K => N missense 8.243e-06 1 121308 0 0.27 0.003
adrb2_human 98 23.49x49 ECL1 M => T missense 8.242e-06 1 121328 0 0.97 0.005
adrb2_human 116 3.35x35 TM3 C => R missense 2.471e-05 3 121412 0 0.0 1.0
adrb2_human 128 3.47x47 TM3 A => S missense 0.0001812 22 121412 0 0.04 0.871
adrb2_human 136 3.55x55 TM3 T => I missense 8.236e-06 1 121412 0 0.03 0.69 GP (contact)
adrb2_human 140 34.52x52 ICL2 K => E missense 8.236e-06 1 121412 0 0.0 0.04 GP (contact)
adrb2_human 140 34.52x52 ICL2 K => M missense 8.236e-06 1 121412 0 0.0 0.731 GP (contact)
adrb2_human 151 4.43x43 TM4 R => W missense 1.647e-05 2 121412 0 0.07 0.96
adrb2_human 156 4.48x48 TM4 M => I missense 1.647e-05 2 121412 0 0.23 0.001
adrb2_human 157 4.49x49 TM4 V => M missense 8.236e-06 1 121412 0 0.0 0.998
adrb2_human 164 4.56x56 TM4 T => I missense 0.009455 1148 121412 18 1.0 0.008
adrb2_human 172 4.64x64 TM4 H => R missense 8.237e-06 1 121410 0 0.1 0.515
adrb2_human 178 ECL2 H => Q missense 9.06e-05 11 121412 0 0.07 0.017
adrb2_human 179 ECL2 Q => E missense 2.471e-05 3 121412 0 1.0 0.0
adrb2_human 179 ECL2 Q => R missense 1.647e-05 2 121412 0 0.31 0.0
adrb2_human 186 ECL2 A => T missense 1.647e-05 2 121412 0 0.4 0.001
adrb2_human 186 ECL2 A => D missense 8.237e-06 1 121410 0 0.74 0.001
adrb2_human 187 ECL2 N => S missense 0.0004859 59 121412 0 0.05 0.007
adrb2_human 213 5.52x52 TM5 V => A missense 2.471e-05 3 121412 0 0.06 0.142
adrb2_human 216 5.55x55 TM5 V => I missense 0.0001483 18 121412 1 1.0 0.007
adrb2_human 220 5.59x59 TM5 S => C missense 0.002512 305 121412 5 0.18 0.909
adrb2_human 220 5.59x59 TM5 S => F missense 8.236e-06 1 121412 0 0.48 0.869
adrb2_human 221 5.60x60 TM5 R => S missense 2.471e-05 3 121412 0 0.0 0.188
adrb2_human 228 5.67x67 TM5 R => K missense 8.236e-06 1 121412 0 1.0 0.001 GP (contact)
adrb2_human 233 5.72x72 TM5 I => T missense 2.471e-05 3 121396 0 0.0 1.0 GP (contact)
adrb2_human 235 5.74x74 TM5 K => R missense 8.238e-06 1 121396 0 0.56 0.012 GP (contact)
adrb2_human 243 ICL3 Q => K missense 8.239e-06 1 121374 0 0.12 0.023
adrb2_human 244 ICL3 N => K missense 8.239e-06 1 121374 0 0.28 0.719
adrb2_human 247 ICL3 Q => H missense 0.0001236 15 121372 0 0.13 0.179
adrb2_human 252 ICL3 G => E missense 8.239e-06 1 121370 0 0.08 0.049
adrb2_human 253 ICL3 R => W missense 8.24e-06 1 121358 0 0.0 0.096
adrb2_human 257 ICL3 G => R missense 8.239e-06 1 121368 0 0.68 0.196
adrb2_human 259 ICL3 R => C missense 8.239e-06 1 121372 0 0.0 0.973
adrb2_human 259 ICL3 R => H missense 4.119e-05 5 121374 0 0.01 0.96
adrb2_human 265 6.27x27 TM6 C => F missense 8.238e-06 1 121394 0 0.35 0.007 LB (Van der Waals)
adrb2_human 276 6.38x38 TM6 G => S missense 1.647e-05 2 121406 0 0.02 0.975
adrb2_human 290 6.52x52 TM6 F => V missense 8.236e-06 1 121412 0 0.0 1.0 LB (aromatic (edge-to-face), Van der Waals, hydrophobic)
adrb2_human 292 6.54x54 TM6 V => I missense 1.647e-05 2 121412 0 0.1 0.264
adrb2_human 292 6.54x54 TM6 V => D missense 8.236e-06 1 121412 0 0.0 0.987
adrb2_human 296 6.58x58 TM6 H => R missense 8.236e-06 1 121412 0 0.42 0.358
adrb2_human 297 6.59x59 TM6 V => M missense 3.295e-05 4 121410 0 0.0 0.801
adrb2_human 300 ECL3 D => N missense 8.237e-06 1 121410 0 0.09 0.006
adrb2_human 301 ECL3 N => S missense 8.237e-06 1 121410 0 0.54 0.021
adrb2_human 304 7.31x30 TM7 R => C missense 1.647e-05 2 121410 0 0.02 0.034
adrb2_human 307 7.34x33 TM7 V => L missense 8.237e-06 1 121408 0 1.0 0.002
adrb2_human 320 7.47x47 TM7 G => D missense 8.237e-06 1 121406 0 0.0 0.19
adrb2_human 324 7.51x51 TM7 L => F missense 8.237e-06 1 121404 0 0.04 0.351
adrb2_human 325 7.52x52 TM7 I => T missense 8.237e-06 1 121402 0 0.0 0.997
adrb2_human 328 7.55x55 TM7 R => W missense 8.238e-06 1 121394 0 0.0 0.942 LB (Van der Waals) GP (contact)
adrb2_human 328 7.55x55 TM7 R => Q missense 3.295e-05 4 121396 0 0.0 0.198 LB (Van der Waals) GP (contact)
adrb2_human 328 7.55x55 TM7 R => L missense 8.238e-06 1 121396 0 0.0 0.055 LB (Van der Waals) GP (contact)
adrb2_human 329 8.47x47 H8 S => N missense 8.238e-06 1 121396 0 0.0 0.026 LB (polar (hydrogen bond), Van der Waals) GP (contact)
adrb2_human 333 8.51x51 H8 R => S missense 1.648e-05 2 121392 0 0.0 0.988 GP (contact)
adrb2_human 334 8.52x52 H8 I => N missense 8.238e-06 1 121394 0 0.29 0.001
adrb2_human 340 8.58x58 H8 L => P missense 1.648e-05 2 121390 0 0.0 0.995
adrb2_human 343 C-term R => H missense 8.238e-06 1 121384 0 0.14 0.022
adrb2_human 346 C-term S => P missense 8.238e-06 1 121394 0 0.19 0.265 PTM (Phosphorylation (PRKCD))
adrb2_human 349 C-term A => S missense 2.471e-05 3 121392 0 0.81 0.008
adrb2_human 357 C-term N => S missense 8.239e-06 1 121374 0 0.27 0.004 LB (hydrophobic, Van der Waals, aromatic (edge-to-face))
adrb2_human 358 C-term G => R missense 6.592e-05 8 121358 0 0.02 0.006
adrb2_human 364 C-term S => N missense 8.246e-06 1 121278 0 0.74 0.001 PTM (Phosphorylation)
adrb2_human 367 C-term H => D missense 8.268e-06 1 120948 0 0.36 0.021
adrb2_human 369 C-term E => Q missense 8.297e-06 1 120530 0 0.56 0.013
adrb2_human 370 C-term Q => K missense 0.0001495 18 120416 0 0.23 0.0
adrb2_human 370 C-term Q => E missense 8.305e-06 1 120416 0 0.51 0.0
adrb2_human 374 C-term N => K missense 8.395e-06 1 119112 0 0.62 0.003
adrb2_human 375 C-term K => R missense 8.401e-06 1 119032 0 0.23 0.013 LB (hydrophobic, Van der Waals)
adrb2_human 382 C-term P => R missense 8.548e-06 1 116988 0 0.27 0.009 PTM (Hydroxylation)
adrb2_human 383 C-term G => D missense 8.562e-06 1 116790 0 0.35 0.079 LB (Van der Waals)
adrb2_human 384 C-term T => K missense 1.717e-05 2 116458 0 0.91 0.014 PTM (Phosphorylation (GRK5))
adrb2_human 384 C-term T => M missense 8.587e-06 1 116458 0 0.13 0.003 PTM (Phosphorylation (GRK5))
adrb2_human 386 C-term D => V missense 1.722e-05 2 116138 0 0.02 0.138
adrb2_human 389 C-term G => S missense 8.648e-06 1 115640 0 0.75 0.0
adrb2_human 392 C-term G => S missense 3.473e-05 4 115176 0 nan 0.437
adrb2_human 394 C-term V => M missense 8.706e-06 1 114858 0 nan 0.569
adrb2_human 395 C-term P => A missense 8.724e-06 1 114622 0 nan 0.013 PTM (Hydroxylation)
adrb2_human 397 C-term D => N missense 8.745e-06 1 114350 0 0.58 0.0
adrb2_human 406 C-term C => F missense 8.77e-06 1 114030 0 nan 0.006
adrb2_human 407 C-term S => G missense 3.509e-05 4 113996 0 nan 0.01 PTM (Phosphorylation (GRK5))
adrb2_human 407 C-term S => N missense 1.755e-05 2 113974 0 nan 0.0 PTM (Phosphorylation (GRK5))


Residue

Diagrams

ICL1 E R L Q ICL1ECL1 M W T F ECL1ICL2 P F K Y Q S L L ICL2ECL2 W Y R A T H Q E A I N C Y A N E T C C D F F T ECL2ICL3 G R F H V Q N L S Q V E Q D G R T G H G L R R S ICL3ECL3 D N L I ECL3N-term M G Q P G N G S A F L L A P N G S H A P D H D V T N-termC-term L R R S S L K A Y G N G Y S S N G N T G E Q S G Y H V E Q E K E N K L L C E D L P G T E D F V G H Q G T V P S D N I D S Q G R N C S T N D S L L C-term Q E R D E V W V V G M G I V M S L I V L A I V F G N V L V I T A I A K F T V T N Y F I T S L A C A D L V M G L A V V P F G A A H I L M K G N F W C E F W T S I D V L C V T A S I E T L C V I A V D R Y F A I T S T K N K A R V I I L M V W I V S G L T S F L P I Q M H N Q A Y A I A S S I V S F Y V P L V I M V F V Y S R V F Q E A K R Q L Q K I D K S E S K F C L K E H K A L K T L G I I M G T F T L C W L P F F I V N I V H V I Q R K E V Y I L L N W I G Y V N S G F N P L I Y C R S P D F Q E F R I A L L C
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